Process Safety Chemist

at Promega
Location Fitchburg, WI
Date Posted April 28, 2021
Category Bioscience
Job Type Full-time
Address 2800 Woods Hollow Rd


Job Description

Promega is an international bio-tech company with over 4000 high quality products that have been supporting science for over 40 years.  We support scientists researching life and disease, pharma companies developing new treatments, forensic labs matching DNA from crime scenes and clinical labs running and confirming health tests - and that’s just the beginning. And yes, we have been extremely busy providing our technologies to support COVID-19 testing and research.


We strive to create an open, inviting and inclusive culture – we care about you as a person, not just a team member.  We embrace the principles of emotional and social intelligence – which helps our employees improve relationships, manage stress and enhance connections.  Establishing and maintaining relationships is part of the foundation of our culture - teams are more like family than co-workers.


Our campus speaks volumes. Headquartered in Madison, employees work in and around a campus with multiple buildings that are integrated into a natural setting with trails, ponds, woods and a restored prairie.  Sustainability is important – we invest in energy efficiency and use renewable energy.  Our culinary team offers top notch food to employees – including an onsite garden to supply fresh produce.  Check out our campus through this map, and learn more about the our people and sustainable practices.



The Promega Component Manufacturing Center team consists of innovative professionals with diverse skillsets who work together to achieve our goal to safely manufacture high-quality small molecules that are used in Promega’s Life Science products to improve lives around the globe.  To achieve this goal, we build strong relationships, collaborate openly, and embrace an attitude of “How can we do this the right way?” when we face challenges.  We believe that to succeed as a team we need to create a space of optimistic learning and shared belonging, leveraging each other’s strengths and celebrating our differences.  We are looking to build our team with members who share these values and who are inspired to take on the new opportunities that inevitably await!



As our process safety subject matter expert, you will be involved with establishing a process safety lab in our new facility and will refine and further develop the process safety framework and workflow.  You will collaborate with chemists and engineers to design and run hazard evaluation experiments to explore thermal liabilities, gas evolution, energy release potential, shock hazards, etc. of reactions.



We are seeking a Chemist or Chemical Engineer with significant process safety experience in the chemical process industry.  An ideal candidate would also have experience in process development of organic chemistry synthesis.


JOB OBJECTIVE: Serves as a collaborative partner supporting new product development from the early chemistry research phase through manufacturing at scales up to 500 gallons. Accountable for proactively identifying process and chemical safety hazards for both new and existing processes in order to help teams understand and minimize chemical reaction and operational risks. This is achieved by providing expertise in data analysis to collaboratively guide the safety evaluation of processes to ensure a safe manufacturing procedure.



1. Initially will be involved with establishing an onsite lab, refining and further developing the process safety framework and workflow, writing SOPs, and becoming the process safety program point of contact.

2. Actively contributes to safety analyses on tech transfer, process development, process improvement, and new product realization teams.

3. Collaborates with chemists and engineers to design and run hazard evaluation experiments using DSC, EasyMax, RC1, and/or other equipment.

4. Contributes to identifying chemically unstable intermediates and reaction mixtures and reviews proposed operating conditions to consider sufficient safety margin from the onset of undesired thermal decompositions.

5. Explores thermal liabilities, gas evolution, energy release potential, shock hazards, etc. of reactions.

6. Explores concerns regarding reagent instability, combustibility, toxicity and potential waste material incompatibilities.

7. Interprets testing results, provides findings and recommendations to understand process safety risks, and pursues more advanced hazard assessment techniques as needed.

8. Assists with identifying safe operating limits for manufacturing equipment (i.e. heat addition/heat removal capabilities of reactors, max and min temperatures, max addition rates, etc.)

9. Participates in PHA/Hazop studies and contributes to process hazard evaluation and process deviation reports.

10. Trains personnel on process safety concepts.

11. Serves as subject matter expert on chemical hazards, including reactive chemistry, chemical kinetics, transport phenomena, etc.

12. Exhibits a collaborative nature by maintaining a strong working relationship with multiple functional groups including Production, Development, Research, Engineering, Analytical, and EH&S.

13. Maintains and manages process safety testing equipment and provides recommendations for additional equipment or testing needs.

14. Stays up to date on novel engineering and chemical process control measures; communicates this knowledge to development teams.

15. Ensures consistent and thorough documentation of process safety information including safety improvements implemented and lessons learned to allow for future application of information.

16. Participates in Change Control evaluations, providing input whether a change potentially impacts the safety of a process.

17. Understands and complies with ethical, legal and regulatory requirements applicable to our business.


1. BS +5 years of work experience in Chemical Engineering, Chemistry, or a related scientific discipline. MS and 3+ years, or PhD and some process safety specific experience.

2. 5+ years of experience in a process safety role in the chemical process industry with a strong knowledge of unit operations and process safety practices.

3. Proven foundational understanding of organic chemistry with laboratory experience

4. Experience with calorimetry testing, including design and execution of experiments, use of various testing instruments, and interpretation of results.

5. Experience with ASTM CHETAH program, running and interpreting hazard evaluation experiments, and hazard evaluation literature including Bretherick's Handbook of Reactive Chemical Hazards.

6. Deep understanding of the interplay between thermodynamic and kinetic effects in producing observed calorimetry results.

7. Proficient in thermodynamics, particularly in the use of equations of state and physical property estimation.

8. Demonstrated ability to communicate effectively by being approachable, thoughtful, and diplomatic.

9. Demonstrated ability to be open and adaptable while also being compassionately firm. Able to maintain balance between opposing drivers.

10. Demonstrated ability to relate to and interact with a large group of people with diverse needs and goals.



1. Experience in process development of organic chemistry synthesis for optimization and scale-up with an understanding of modern analytical methods (HPLC, NMR, TLC, etc).


2. Demonstrates the ability to design and conduct chemical experiments for the development of robust manufacturing processes through the use of statistical analysis tools (DoE), mass and energy balances, and process robustness studies with lab-scale representative equipment.



1. Must be able to move about the building, the labs, and offices while performing the tasks described above.

2. Must be able to stand for moderate periods of time.

3. Must be able to lift and carry 25 pounds on an occasional basis.

4. Must be able to stoop, bend, crouch, kneel, push and pull, climb stairs and ladders on an occasional basis.

5. Must be able to use a computer.

6. Ability to use standard laboratory personal protective equipment (e.g. safety glasses, lab coat, protective gloves).

7. Ability to work in a production environment around automated equipment.

8. Ability to travel by car or airplane, for one or several days, to suppliers, equipment vendors, trade shows, etc.


Click here to learn more & apply today!